Molecular Formula | C6H5ClN2O2 |
Molar Mass | 172.57 |
Density | 1.372±0.06 g/cm3(Predicted) |
Boling Point | 304.3±15.0 °C(Predicted) |
Appearance | solid |
pKa | -3.78±0.20(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.534 |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | 36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
WGK Germany | 3 |
HS Code | 29335990 |
overview | methyl 2-chloropyrimidine-4-formate is an ester organic substance and can be used as an intermediate in pharmaceutical synthesis. |
application | methyl 2-chloropyrimidin-4-formate can be used as an intermediate in pharmaceutical synthesis. For example, 1-(2-chloropyrimidin-4-yl)-4, 4-dimethylpent-1, 3-dione can be prepared, and then 4-(3-tert-butyl-1H-pyrazole -5-yl)-2-chloropyrimidine can be further prepared. |
preparation | preparation of 2-chloropyrimidin-4-formate: the specific steps are as follows: dissolving 2-chloropyrimidin-4-formic acid (4.76g,30mmol) in dichloromethane (30mL) and dimethylformamide (0.3mL), slowly add oxalyl chloride (5.72g,45mmol) to it, stir at room temperature for 2 hours, concentrate to an appropriate volume, add it dropwise to anhydrous methanol (50mL) placed in an ice bath, transfer the reaction to room temperature for 2 hours, and concentrate under reduced pressure to obtain the product 2-chloropyrimidine-4-methyl formate (5.17g, yield 100%). |